| 4. | Patterson, M. T.*, Firulyova, M. M., Xu, Y., Hillman, H., Bishop, C., Zhu, A., Hickok, G. H., Schrank, P. R., Ronayne, C. E., Caillot, Z., Fredrickson, G., Kennedy, A. E., Acharya, N., Neels, J. G., Chinetti, G., Revelo, X., Stromnes, I. M., Ivanov, S., Bold, T. D., Zaitsev, K., Williams, J. W. (2023). Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis. Nature Cardiovascular Research. 2, 1015-1031. PMID: 38646595 |
| 5. | Patterson, M. T.*, Burrack, A. L., Xu, Y., Hickok, G. H., Schmiechen, Z. C., Becker, S., Cruz-Hinojoza, E., Schrank, P. R., Kennedy, A. E., Firulyova, M. M., Miller, E. A., Zaitsev, K., Williams, J. W., Stromnes, I. (2023). Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma. Cell Reports, 42(7). PMID: 37402168 |
| 6. | Zhang N., Harsch, B., Zhang, M., Gyberg, D. J., Stevens, J. A., Wagner, B. M., Mendelson, J., Patterson, M. T., Orchard, D. A., Healy, C. L., Williams, J. W., Townsend, D., Shearer, G. C., Murphy, K. A., O'Connell, T. D. (2023). FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome. Journal of Lipid Research, 64(6), 100374. PMID: 37075982 |
| 7. | Dolfi, B., Gallerand, A., Firulyova, M., Merlin, J., Castiglione, A., Khedher, N., Vaillant, N., Stunault, M., Gilleron, J., Wakkach, A., Schrank, P., Xu, Y., Blin, C., Becher, B., Pagnotta, S., Lacas-Gervais, S., Zaitsev, K., Kim, K., Yvan-Charvet, L., Guinamard, R. R., Williams, J. W., Ivanov, S. (2022). Unravelling the sex-specific diversity and functions of adrenal gland macrophages. Cell Reports, 39(11), 110949. PMID: 35705045 |
| 8. | Xu, Y.*, Schrank, P. R., Williams, J. W. (2022). Macrophage fate mapping. Current Protocols in Immunology, 2(6), e456. PMID: 35687806 |
| 9. | Zhang, N., Kim, S. H., Gainullina, A., Erlich, E. C., Onufer, E. J., Kim, J., Czepielewski, R. S., Helmink, B. A., Dominguez, J. R., Saunders, B. T., Ding, J., Williams, J. W., Jiang, J. X., Segal, B. H., Zinselmeyer, B. H., Randolph, G. J., Kim, K.-W. (2021). LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth. Journal of Experimental Medicine, 218(12), 1-14. PMID: 34714329 |
| 10. | Huggins, D. N., LaRue, R. S., Wang, Y., Knutson, T. P., Williams, J. W., Schwertfeger, K. (2021). Characterizing macrophage diversity in metastasis-bearing lungs reveals a lipid-associated macrophage subset. Cancer Research, 81(20), 5284-5295. PMID: 34389631 |
| 11. | Patterson, M. T.*, & Williams, J. W. (2021). Metabolic regulation of macrophage proliferation and function in atherosclerosis. Current Opinion in Lipidology, 32(5), 293-300. PMID: 34334628 |
| 12. | Gallerand, A., Stunault, M. I., Merlin, J., Luehmann, H., Sultan, D., Firulyova, M. M., Magnone, V., Khedher, N., Jalil, A., Dolfi, B., Castiglione, A., Dumont, A., Ayrault, M., Vaillant, N., Gilleron, J., Barbry, P., Dombrowicz, D., Mack, M., Masson, D., Bertero, T., Becher, B., Williams, J. W., Zaitsev, K., Liu, Y., Guinamard, R. R., Yvan-Charvet, L., Ivanov, S. (2021). Brown adipose tissue monocytes support tissue expansion. Nature Communications, 6(12), 5255. PMID: 34489438 |
| 13. | Detering, L., Abdilla, A., Luehmann, H. P., Williams, J. W., Huang, L.-H., Sultan, D., Elvington, A., Heo, G. S., Woodard, P. K., Gropler, R. J., Randolph, G. J., Hawker, C. J., Liu, Y. (2021). CC chemokine receptor 5 targeted nanoparticles imaging the progression and regression of atherosclerosis using positron emission tomography/computed tomography. Molecular Pharmaceutics, 1(18), 1386-1396. PMID: 33591187 |
| 14. | Brestoff, J. R., Wilen, C. B., Moley, J. R., Li, Y., Zou, W., Malvin, N. P., Rowen, M. N., Saunders, B. T., Ma, H., Mack, M. R., Hykes Jr, B. L., Balce, D. R., Orvedahl, A., Williams, J. W., Rohatgi, N., Wang, X., McAllaster, M. R., Handley, S. A., Kim, B. S., Doench, J. G., Zinselmeyer, B. H., Diamond, M. S., Virgin, H., Gelman, A. E., Teitelbaum, S. L. (2021). Intercellular mitochondria transfer regulates macrophage function and maintains glucose homeostasis. Cell Metabolism, 33(2), 1-13. PMID: 33278339 |
| 15. | Kim, K.-W., Ivanov, S., Williams, J. W. (2020). Monocyte recruitment, specification, and function in atherosclerosis. Cells, 10(1), 15. PMID: 33374145 |
| 16. | Williams, J. W., Zaitzev, K., Kim, K.-w., Ivanov, S., Saunders, B.T., Kim, K., Elvington, A., Schrank, P. R., Kim, K., Elvington, A., Kim, S-H, Tucker, C.G., Wohltmann, Fife, B.T., M., Epelman, S., Artyomov, M., Lavine, K., Zinselmeyer, B., Choi, J.-H., Randolph, G. J.. (2020). Limited proliferation capacity of aorta intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression. Nature Immunology, 21(10), 1194-1204. PMID: 32895539 |
| 17. | Zernecke, A., Winkels, H., Cochain, C., Williams, J. W., Wolf, D., Soehnlein, O., Robbins, C. S., Monaco, C., Park, I., McNamara, C. A., Binder, C. J., Cybulsky, M. I., Scipione, C. A., Hedrick, C. C., Galkina, E. V., Kyaw, T., Ghosheh, Y., Dinh, H. Q., Ley, K. (2020). Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas. Circulation Research, 17(127), 402-426. PMID: 32673538 |
| 18. | Zou, W., Rohatgi, N., Brestoff, J. R., Moley, J. R., Li, Y., Williams, J. W., Alippe, Y., Pan, H., Pietka, T., Mbalaviele, G., Newberry, E. P., Davidson, N. O., Dey, A., Shoghi, K. I., Head, R. D., Wickline, S. A., Randolph, G. J., Abumrad, N. A., Teitelbaum, S. L. (2020). Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure. Journal of Clinical Investigation, 130(5), 2644-2656. PMID: 32310225 |
| 19. | Evans, S., Weinheimer, C. J., Kovacs, A., Williams, J. W., Randolph, G. J., Jiang, W., Barger, P. M., Mann, D. L. (2020). Ischemia reperfusion injury provokes adverse left ventricular remodeling in dysferlin-deficient hearts through a pathway that involves TIRAP dependent signaling. Scientific Reports, 10(1), 14129. PMID: 32839504 |
| 20. | Williams, J. W., Winkels, H., Durant, C., Zaitsev, K., Ghosheh, Y., Ley, K. (2020). Single Cell RNA-sequencing in atherosclerosis. Circulation Research, 126(9), 1112-1126. PMID: 32324494 |
| 21. | Adamo, L., Rocha-Resende, C., Lin, C.-Y., Evans, S., Williams, J. W., Dun, H., Li, W., Mpoy, C., Rogers, B., Kreisel, D., Lavine, K., Randolph, G. J., Mann, D. L. (2020). Myocardial B cells are a subset of circulating B cells that modulate the myocardial leukocyte pool composition and myocardial mass. JCI Insight, 5(3), e134700. PMID: 31945014 |
| 22. | Williams, J. W., Huang, L.-h., & Randolph, G. J. (2019). Cytokine circuits in cardiovascular disease. Immunity, 50(4), 941--954. PMID: 30995508 |
| 23. | Parker-Harp, C. R., Archambault, A. S., Cheung, M., Williams, J. W., Czepielewski, R. S., Duncker, P. C., Kilgore, A. J., Miller, A. T., Segal, B. M., Kim, A. H., Randolph, G. J., Wu, G. F. (2019). Neutrophils promote VLA-4-dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation. Proceedings of the National Academy of Sciences, 116(48), 24221--24230. PMID: 31699814 |
| 24. | Buechler, M. B., Kim, K.-W., Onufer, E. J., Williams, J. W., Little, C. C., Dominguez, C. X., Li, Q., Sandoval, W., Cooper, J. E., Harris, C. A., Junttila, M. R., Randolph, G. J., Turley, S. J. (2019). A stromal niche defined by expression of the transcription factor WT1 mediates programming and homeostasis of cavity-resident macrophages. Immunity, 51(1), 119-130. PMID: 31231034 |
| 25. | Williams, J. W., Elvington, A., Kessler, S., Wohltmann, M., Wu, G. F., Randolph, G. J. (2019). B cell-mediated antigen presentation through MHC class II is dispensable for atherosclerosis progression. ImmunoHorizons, 3(1), 37--44. PMID: 31356175 |
| 26. | Williams, J. W., Ferreira, C. M., Blaine, K. M., Rayon, C., Velazquez, F., Tong, J., Peter, M. E., Sperling, A. I. (2018). Non-apoptotic Fas (CD95) signaling on T cells regulates the resolution of Th2-mediated inflammation. Frontiers in Immunology, 9, 2521. PMID: 30443253 |
| 27. | Ferreira, C. M., Williams, J. W., Tong, J., Rayon, C., Blaine, K. M., Sperling, A. I. (2018). Allergen exposure in lymphopenic Fas-deficient mice results in persistent eosinophilia due to defects in resolution of inflammation. Frontiers in Immunology, 9, 2395. PMID: 30425708 |
| 28. | Williams, J. W., Giannarelli, C., Rahman, A., Randolph, G. J., Kovacic, J. C. (2018). Macrophage biology, classification, and phenotype in cardiovascular disease: JACC macrophage in CVD series (part 1). Journal of the American College of Cardiology, 72(18), 2166--2180. PMID: 30360826 |
| 29. | Kim, K., Shim, D., Lee, J. S., Zaitsev, K., Williams, J. W., Kim, K.-W., Jang, M.-Y., Jang, H. S., Yun, T. J., Lee, S. H., Yoon, W. K., Prat, A., Seidah, N. G., Choi, J., Lee, S.-P., Yoon, S.-H., Nam, J. W., Seong, J. K., Oh, G. T., Randolph, G. J., Artyomov, M. N., Cheong, C., Choi, J.-H. (2018). Transcriptome analysis reveals nonfoamy rather than foamy plaque macrophages are proinflammatory in atherosclerotic murine models. Circulation Research, 123(10), 1127--1142. PMID: 30359200 |
| 30. | Williams, J. W., Martel, C., Potteaux, S., Esaulova, E., Ingersoll, M. A., Elvington, A., Saunders, B. T., Huang, L.-H., Habenicht, A. J., Zinselmeyer, B. H., Randolph, G. J. (2018). Limited macrophage positional dynamics in progressing or regressing murine atherosclerotic plaques. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1702-1710. PMID: 29903736 |
| 31. | Turecamo, S. E., Walji, T. A., Broekelmann, T. J., Williams, J. W., Ivanov, S., Wee, N. K., Procknow, J. D., McManus, M. R., Randolph, G. J., Scheller, E. L., Mecham, R. P., Craft, C. S. (2018). Contribution of metabolic disease to bone fragility in MAGP1-deficient mice. Matrix Biology, 67, 1--14. PMID: 29519758 |
| 32. | Hrusch, C. L., Manns, S. T., Bryazka, D., Casaos, J., Bonham, C. A., Jaffery, M. R., Blaine, K. M., Mills, K. A., Verhoef, P. A., Adegunsoye, A. O., Williams, J. W., Moore, T. V., Strek, M. E., Noth, I., Sperling, A. I. (2018). ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunology, 11(1), 61. PMID: 28488693 |
| 33. | Williams, J. W., Elvington, A., Ivanov, S., Kessler, S., Luehmann, H., Baba, O., Saunders, B. T., Kim, K.-W., Johnson, M. W., Craft, C. S., Choi, J.-H., Sorci-Thomas, M. G., Zinselmeyer, B. H., Brestoff, J. R., Liu, Y., Randolph, G. J. (2017). Thermoneutrality but not UCP1 deficiency suppresses monocyte mobilization into blood. Circulation Research, 121(6), 662--676. PMID: 28696252 |
| 34. | Williams, J. W., Randolph, G. J., & Zinselmeyer, B. H. (2017). A polecat's view of patrolling monocytes. Circulation Research, 120(11), 1699-1701. PMID: 28546349 |
| 35. | Ivanov, S., Scallan, J. P., Kim, K.-W., Werth, K., Johnson, M. W., Saunders, B. T., Wang, P. L., Kuan, E. L., Straub, A. C., Ouhachi, M., Weinstein, E. G., Williams, J. W., Colonna, M., Isakson, B. E., Gautier, E. L., Forster, R., Zinselmeyer, B. H., Randolph, G. J. (2016). CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. Journal of Clinical Investigation, 126(4), 1581--1591. PMID: 26999610 |
| 36. | Kim, K.-W., Williams, J. W., Wang, Y.-T., Ivanov, S., Gilfillan, S., Colonna, M., Virgin, H. W., Gautier, E. L., Randolph, G. J. (2016). MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. Journal of Experimental Medicine, 213(10), 1951--1959. PMID: 27551152 |
| 37. | Ensan, S., Li, A., Besla, R., Degousee, N., Cosme, J., Roufaiel, M., Shikatani, E. A., El-Maklizi, M., Williams, J. W., Robins, L., Li, C., Lewis, B., Yun, T. J., Lee, J. S., Wieghofer, P., Khattar, R., Farrokhi, K., Byrne, J., Ouzounian, M., Zavitz, C. C., Levy, G. A., Bauer, C. M., Libby, P., Husain, M., Swirski, F. K., Cheong, C., Prinz, M., Hilgendorf, I., Randolph, G. J., Epelman, S., Gramolini, A. O., Cybulsky, M. I., Rubin, B. B., Robbins, C. S. (2016). Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth. Nature Immunology, 17(2), 159-168. PMID: 26642357 |
| 38. | Lu, Q., Yokoyama, C. C., Williams, J. W., Baldridge, M. T., Jin, X., DesRochers, B., Bricker, T., Wilen, C. B., Bagaitkar, J., Loginicheva, E., Sergushichev, A., Kreamalmeyer, D., Keller, B. C., Zhao, Y., Kambal, A., Green, D. R., Martinez, J., Dinauer, M. C., Holtzman, M. J., Crouch, E. C., Beatty, W., Boon, A. C., Zhang, H., Randolph, G. J., Artyomov, M. N., Virgin, H. W. (2016). Homeostatic control of innate lung inflammation by Vici syndrome gene Epg5 and additional autophagy genes promotes influenza pathogenesis. Cell Host & Microbe, 19(1), 102--113. PMID: 26764600 |
| 39. | Tjota, M. Y., Hrusch, C. L., Blaine, K. M., Williams, J. W., Barrett, N. A., Sperling, A. I. (2014). Signaling through FcRgamma-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. Journal of Allergy and Clinical Immunology, 134(3), 706--713. PMID: 25088053 |
| 40. | Gautier, E. L., Ivanov, S., Williams, J. W., Huang, S. C.-C., Marcelin, G., Fairfax, K., Wang, P. L., Francis, J. S., Leone, P., Wilson, D. B., Artyomov, M. N., Pearce, E. J., Randolph, G. J. (2014). Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. Journal of Experimental Medicine, 211(8), 1525--1531. PMID: 25024137 |
| 41. | Williams, J. W., Tjota, M. Y., Clay, B. S., Vander Lugt, B., Bandukwala, H. S., Hrusch, C. L., Decker, D. C., Blaine, K. M., Fixsen, B. R., Singh, H., Sciammas, R., Sperling, A. I. (2013). Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nature Communications, 4, 2990. PMID: 24356538 |
| 42. | Williams, J. W., Yau, D., Sethakorn, N., Kach, J., Reed, E. B., Moore, T. V., Cannon, J., Jin, X., Xing, H., Muslin, A. J., Sperling, A. I., Dulin, N. O. (2013). RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology, 305(10), L693--L701. PMID: 24077945 |
| 43. | Wu, Q., Gardiner, G. J., Berry, E., Wagner, S. R., Lu, T., Clay, B. S., Moore, T. V., Ferreira, C. M., Williams, J. W., Luster, A. D., Medoff, B. D., Cannon, J. L., Sperling, A. I., Shilling, R. A. (2013). ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. PloS One, 8(8), e72955. PMID: 23967339 |
| 44. | Kach, J., Sandbo, N., Sethakorn, N., Williams, J. W., Reed, E. B., La, J., Tian, X., Brain, S. D., Rajendran, K., Krishnan, R., Sperling, A. I., Birukov, K., Dulin, N. O. (2013). Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. American Journal of Physiology-Lung Cellular and Molecular Physiology, 304(11), L757--L764. PMID: 23585227 |
| 45. | Tjota, M. Y., Williams, J. W., Lu, T., Clay, B. S., Byrd, T., Hrusch, C. L., Decker, D. C., de Araujo, C. A., Bryce, P. J., Sperling, A. I. (2013). IL-33-dependent induction of allergic lung inflammation by FcgammaRIII signaling. Journal of Clinical Investigation, 123(5), 2287--2297. PMID: 23585480 |
| 46. | Shilling, R. A., Williams, J. W., Perera, J., Berry, E., Wu, Q., Cummings, O. W., Sperling, A. I., Huang, H. (2013). Autoreactive T and B cells induce the development of bronchus-associated lymphoid tissue in the lung. American Journal of Respiratory Cell and Molecular Biology, 48(4), 406--414. PMID: 23371062 |
| 47. | Williams, J. W., Tjota, M. Y., Sperling, A. I. (2012). The contribution of allergen-specific IgG to the development of Th2-mediated airway inflammation. Journal of Allergy, 2012, 236075. PMID: 23150737 |
| 48. | Schneider, H., Fritzky, L., Williams, J. W., Heumann, C., Yochum, M., Pattar, K., Noppert, G., Mock, V., Hawley, E. (2012). Cloning and expression of a zebrafish 5-HT2C receptor gene. Gene, 502(2), 108--117. PMID: 22521866 |
| 49. | Zloza, A., Kohlhapp, F. J., Lyons, G. E., Schenkel, J. M., Moore, T. V., Lacek, A. T., O'Sullivan, J. A., Varanasi, V., Williams, J. W., Jagoda, M. C., Bellavance, E. C., Marzo, A. L., Thomas, P. G., Zafirova, B., Polic, B., Al-Harthi, L., Sperling, A. I., Guevara-Patino, J. A. (2012). NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses. Nature Medicine, 18(3), 422-428. PMID: 22366950 |
| 50. | Moore, T. V., Clay, B. S., Ferreira, C. M., Williams, J. W., Rogozinska, M., Cannon, J. L., Shilling, R. A., Marzo, A. L., Sperling, A. I. (2011). Protective effector memory CD4 T cells depend on ICOS for survival. PLoS One, 6(2), e16529. PMID: 21364749 |
| 51. | Tong, J., Clay, B. S., Ferreira, C. M., Bandukwala, H. S., Moore, T. V., Blaine, K. M., Williams, J. W., Hoffman, L. M., Hamann, K. J., Shilling, R. A., Weinstock, J. V., Sperling, A. I. (2010). Fas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma. American Journal of Respiratory Cell and Molecular Biology, 43(3), 342--348. PMID: 19855087 |
