The Williams Lab is in the Department of Integrative Biology and Physiology (IBP) at the University of Minnesota Medical School. Our lab is part of the Center for Immunology, located in the Winston and Maxine Wallin Medical Biosciences Building (WMBB) on the Twin Cities campus.
Our overarching research goal is to determine the contributions of the myeloid cell compartment in the pathogenesis of metabolic and cardiovascular diseases, like atherosclerosis. By understanding cellular heterogeneity, localization, and molecular communication pathways, we can develop models to determine how monocytes and macrophages contribute to inflammation progression, as well as resolution. Using cutting edge approaches including single-cell transcriptomics, intravital imaging, and new animal models, we aim to push current boundaries in cardiovascular research into translatable findings by identifying targetable pathways to modify cardiovascular risk associated with chronic vascular inflammation.